Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus. Recent studies published in PloS Pathogens, Nature and Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design. Research interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world.
More specifically, the reconstitution of the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TB , and pathogenesis such as the Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.
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The initial focus on trauma and resilience has now extended to work in substance use and NeuroHIV. Her research focuses on child lung health including HIV-associated lung disease, childhood pneumonia and childhood TB. In she received the World Lung Health Award, awarded by the American Thoracic Society at a ceremony in San Diego, in recognition of work that has "the potential to eliminate gender, racial, ethnic, or economic health disparities worldwide".
Currently regarded as a thought leader in Rheumatic Heart Disease, both on the continent and internationally. Has significant international research collaborations within the Rheumatic Heart Disease Community and within the Cardiovascular Community. Her social responsibility is reflected in, amongst others, numerous board positions; and she continues to be involved in teaching, training and mentorship encompassing courses directed at nurse practitioners, clinical officers and echocardiography masterclasses in South Africa, Ethiopia, Zambia and Uganda.
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